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Among many factors that may be responsible for the apparent effect of vitamin Ds on all cause mortality is the effect of this vitamin on telomeres (the terminal end of each gene) and its potential effect on slowing aging. Richards and coworkers examined whether vitamin D concentrations could slow the rate of shortening of telomeres on leukocytes (a marker of aging). Leukocyte telomere length (LTL) is predictive of the development of numerous aging related disease, and length of leukocyte telomeres decreases with each cell division and with increased inflammation (more common in the elderly).

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